Targeting a protein to improve treatment for aggressive breast cancer
Targeting PELP1 oncogenic functions in DNA repair for treating triple negative breast cancer
['FUNDING_OTHER'] · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · NIH-10951525
This study is looking at a new way to treat triple negative breast cancer, especially for military women, by exploring how a protein called PELP1 helps cancer grow and repair itself, with the hope that a new treatment can make current therapies work better and cause fewer side effects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTH TEXAS VETERANS HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10951525 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new treatments for triple negative breast cancer (TNBC), which is particularly aggressive and common among military servicewomen. The study investigates the role of a protein called PELP1 in cancer progression and aims to understand how it contributes to DNA repair mechanisms in cancer cells. By using a novel inhibitor of PELP1, researchers hope to enhance the effectiveness of existing therapies while reducing side effects and resistance. This approach could lead to better treatment options for patients with TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with triple negative breast cancer, particularly those with a history of military service.
Not a fit: Patients with other types of breast cancer or those who do not have a diagnosis of triple negative breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective and safer treatment options for patients with triple negative breast cancer.
How similar studies have performed: Other research has shown promise in targeting similar molecular pathways in cancer treatment, suggesting potential for success in this novel approach.
Where this research is happening
SAN ANTONIO, UNITED STATES
- SOUTH TEXAS VETERANS HEALTH CARE SYSTEM — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VADLAMUDI, RATNA K — SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
- Study coordinator: VADLAMUDI, RATNA K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, breast cancer metastasis, Breast Cancer Model