Targeting a protein to help treat PTSD
Controlling FKBP51 for the treatment of PTSD
This study is looking at how a protein called FKBP51 might be linked to PTSD, especially in veterans, and aims to find new treatments that lower this protein to help manage stress and PTSD symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10914542 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, FKBP51, in the development of post-traumatic stress disorder (PTSD) and related neuropsychiatric conditions. It focuses on individuals, particularly veterans, who may have a genetic predisposition to these disorders due to a common genetic variation. The study aims to develop new treatments that reduce FKBP51 levels using a technique called antisense oligonucleotides, and it will utilize mouse models to understand how changes in FKBP51 affect stress responses and PTSD symptoms. By measuring the effects of these treatments, the research seeks to validate FKBP51 as a therapeutic target.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans and individuals with PTSD, particularly those with the rs1360780 genetic variant associated with higher FKBP51 expression.
Not a fit: Patients without PTSD or those who do not carry the rs1360780 genetic variant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate PTSD symptoms and improve the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promise in targeting FKBP51 for therapeutic purposes, indicating that this approach may be viable.
Where this research is happening
Tampa, United States
- James a. Haley VA Medical Center — Tampa, United States (Active)
Researchers
- Principal investigator: Blair, Laura J — James a. Haley VA Medical Center
- Study coordinator: Blair, Laura J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.