Targeting a protein involved in cancer treatment
Official title: A systems-level approach to therapeutically target STING in cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-10981389 · Data updated 2026-11-12
This study is looking at a new way to change a protein called STING that helps your immune system fight cancer, using a special technique to see how different changes can make cancer treatments work better for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $701,876 |
| NIH project number | 1R01CA282762-01A1 |
| Project ID | NIH-10981389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer who may benefit from innovative immunotherapy approaches.
✕Less likely to help
Patients with non-cancerous conditions or those who do not respond to immune-based therapies may not receive benefits from this research.
What this research studies
This research investigates a novel approach to target the STING protein, which plays a crucial role in the immune response against cancer. By utilizing a technology called SatSeq, the researchers aim to systematically alter the STING protein to understand its various functions in cancer therapy. This approach combines single-cell sequencing with saturation mutagenesis to explore how different modifications can enhance the immune system's ability to fight cancer. Patients may benefit from insights gained through this research that could lead to more effective cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against cancer, potentially improving patient outcomes.
How similar studies have gone: Other research has shown promise in targeting immune pathways for cancer treatment, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Laughney, Ashley Marie — Weill Medical Coll of Cornell Univ
- Study coordinator: Laughney, Ashley Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.