Targeting a protein involved in cancer growth
Targeting epigenetic reader GAS41
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10583570
This study is looking at a protein called GAS41 and how it affects certain cancers, like lung cancer and brain tumors, to find new ways to slow down or stop cancer growth, which could lead to better treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10583570 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the GAS41 protein in various cancers, particularly Non-Small Cell Lung Cancer (NSCLC) and glioblastoma. It focuses on how GAS41 interacts with acetylated histones, which are crucial for gene regulation in cancer cells. The researchers aim to develop small molecule inhibitors that can disrupt this interaction, potentially slowing down or stopping cancer cell growth. Patients may benefit from new treatment options that target this specific mechanism of tumorigenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Non-Small Cell Lung Cancer or glioblastoma.
Not a fit: Patients with cancers not associated with GAS41 or those who do not have Non-Small Cell Lung Cancer or glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that specifically inhibit cancer growth by targeting the GAS41 protein.
How similar studies have performed: Other research has shown promise in targeting similar epigenetic mechanisms in cancer treatment, indicating that this approach could be effective.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIERPICKI, TOMASZ — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: CIERPICKI, TOMASZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, NSCLC - Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer