Targeting a new signaling pathway to improve breast cancer therapies
Official title: Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
Funded at Case Western Reserve University · NIH-10746911 · Data updated 2026-11-12
This study is looking at how a group of proteins works together to control the growth of breast cancer cells, with the hope of finding new ways to make treatments more effective for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,999 |
| NIH project number | 4R00CA263194-03 |
| Project ID | NIH-10746911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer who may benefit from novel treatment approaches.
✕Less likely to help
Patients with non-breast cancer types or those who are not currently undergoing treatment for breast cancer may not receive any benefit from this research.
What this research studies
This research investigates how a specific protein complex, known as the anaphase-promoting complex/Cyclosome (APC/C), regulates the cell cycle in breast cancer cells. By focusing on the interactions between proteins CDK4, Cdh1, and Pin1, the study aims to understand how these proteins can be manipulated to enhance the effectiveness of breast cancer treatments. The researchers will explore the phosphorylation of Cdh1 by CDK4 and its subsequent effects on cell cycle regulation, potentially leading to new therapeutic strategies. Patients may benefit from insights gained into how to better target breast cancer therapies based on these molecular interactions.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for breast cancer patients.
How similar studies have gone: Other research has shown promise in targeting similar molecular pathways in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Dang, Fabin — Case Western Reserve University
- Study coordinator: Dang, Fabin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.