Targeting a molecule to improve immune response in sepsis
Targeting immune inhibitory molecule SUSD2 to reverse immunosuppression
This study is looking at how a molecule called SUSD2 affects the immune system during sepsis, and it hopes to find out if blocking SUSD2 can help boost the immune response in patients, making it easier for their bodies to fight off this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11094750 on NIH RePORTER |
What this research studies
This research investigates the role of a molecule called SUSD2 in sepsis, a severe condition that can lead to death. The study aims to understand how blocking SUSD2 can restore the function of immune cells, particularly T lymphocytes, which are often suppressed during sepsis. By using experimental models and patient samples, the researchers will explore the potential of this approach to enhance immune responses and improve survival rates in septic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have experienced sepsis and are facing challenges with immune suppression.
Not a fit: Patients who are not affected by sepsis or have other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune function in patients suffering from sepsis.
How similar studies have performed: Previous studies have shown promise in targeting immune inhibitory molecules to improve immune responses, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Wen, Haitao — Ohio State University
- Study coordinator: Wen, Haitao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.