Targeting a key signaling pathway in pancreatic cancer
Targeting MTOR signaling in pancreatic cancer
This study is looking at how a specific pathway in cells, called the MTOR signaling pathway, affects pancreatic cancer, and it aims to find out if blocking one part of this pathway can help slow down the growth of this tough-to-treat cancer, with hopes of discovering better ways to manage it for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11061838 on NIH RePORTER |
What this research studies
This research investigates the role of the MTOR signaling pathway in pancreatic cancer, particularly focusing on its two complexes, MTORC1 and MTORC2. The study aims to understand how inhibiting MTORC2 can affect the progression of pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of cancer. By using genetically engineered mouse models and human cancer cell lines, researchers will explore the potential of targeting this pathway to improve treatment outcomes. The goal is to identify new therapeutic strategies that could lead to better management of this challenging disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those with specific genetic alterations like KRAS mutations.
Not a fit: Patients with other types of cancer or those whose pancreatic cancer is not driven by KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve survival rates for patients with pancreatic cancer.
How similar studies have performed: Previous studies have shown promising results in targeting similar pathways in other cancers, suggesting potential for success in this approach for pancreatic cancer.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Lewis, Brian C — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lewis, Brian C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.