Targeting a key protein to treat glioblastoma
Targeting Go and Grow in Glioblastoma
This study is looking at a new way to treat glioblastoma, a tough type of brain cancer, by using a safe small molecule that can help slow down tumor growth and improve survival, while also finding ways to make the treatment work even better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10876294 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer, by targeting the myosin II family of molecular motors, which play a crucial role in tumor growth and spread. The approach involves using a non-toxic small molecule inhibitor that can penetrate the central nervous system, aiming to suppress tumor progression and extend survival in preclinical models. The study also explores how to enhance treatment effectiveness by addressing compensatory signaling pathways that may arise when myosin II is inhibited. Overall, the goal is to develop more effective strategies for managing glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that significantly prolong survival for patients with glioblastoma.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in glioblastoma, indicating potential for success with this approach.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Rosenfeld, Steven S — Mayo Clinic Jacksonville
- Study coordinator: Rosenfeld, Steven S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.