Targeting a key protein to treat cancer
Inhibiting Multi-Functional ALDOA for Cancer Therapy
This study is looking at a protein called aldolase A that helps cancer cells grow and spread, especially in pancreatic cancer, and aims to find ways to block its actions to improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phusis Therapeutics, INC. NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-10494262 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called aldolase A (ALDOA) in cancer cells, particularly its involvement in cancer growth and survival. The study aims to inhibit ALDOA's functions, which are linked to increased cancer cell proliferation and metastasis, especially in pancreatic cancer. By understanding how ALDOA interacts with other cellular components, researchers hope to develop new therapeutic strategies that could disrupt these processes. The approach includes exploring the protein's various activities and how they can be targeted to improve cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic cancer or other malignancies where ALDOA is known to play a critical role.
Not a fit: Patients with cancers that do not involve ALDOA or those with early-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with certain types of cancer, particularly pancreatic cancer.
How similar studies have performed: Other research has shown promising results in targeting similar proteins for cancer therapy, indicating that this approach has potential for success.
Where this research is happening
La Jolla, UNITED STATES
- Phusis Therapeutics, INC. — La Jolla, United States (Active)
Researchers
- Principal investigator: Powis, Garth — Phusis Therapeutics, INC.
- Study coordinator: Powis, Garth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.