Targeting a gene to improve brain cell function in Alzheimer's disease
siRNA-mediated Knockdown of INPP5D to Modulate Microglia Activity for the Treatment of Alzheimer's Disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11107595
This study is looking at how a gene called INPP5D affects brain immune cells in people with Alzheimer's, and by tweaking this gene, researchers hope to improve these cells' function and slow down memory loss, which could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11107595 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific gene, INPP5D, in the activity of brain immune cells called microglia, which are crucial in Alzheimer's disease. By using a technique called siRNA to reduce the expression of this gene, the study aims to enhance microglial function and potentially slow down the progression of Alzheimer's. The research involves both genetic analysis and mouse models to understand how modifying this gene can impact cognitive decline and amyloid plaque accumulation. Patients may benefit from new therapeutic strategies that arise from this approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease that improve cognitive function and reduce disease progression.
How similar studies have performed: Previous research has shown promise in targeting microglial function for Alzheimer's treatment, indicating that this approach may lead to significant advancements.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICHARDSON, TIMOTHY I — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: RICHARDSON, TIMOTHY I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia