Targeting a gene to improve brain cell function in Alzheimer's disease
Official title: siRNA-mediated Knockdown of INPP5D to Modulate Microglia Activity for the Treatment of Alzheimer's Disease
Funded at Indiana University Indianapolis · NIH-11107595 · Data updated 2026-11-12
This study is looking at how a gene called INPP5D affects brain immune cells in people with Alzheimer's, and by tweaking this gene, researchers hope to improve these cells' function and slow down memory loss, which could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $792,074 |
| NIH project number | 1R01AG093015-01 |
| Project ID | NIH-11107595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of a specific gene, INPP5D, in the activity of brain immune cells called microglia, which are crucial in Alzheimer's disease. By using a technique called siRNA to reduce the expression of this gene, the study aims to enhance microglial function and potentially slow down the progression of Alzheimer's. The research involves both genetic analysis and mouse models to understand how modifying this gene can impact cognitive decline and amyloid plaque accumulation. Patients may benefit from new therapeutic strategies that arise from this approach.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease that improve cognitive function and reduce disease progression.
How similar studies have gone: Previous research has shown promise in targeting microglial function for Alzheimer's treatment, indicating that this approach may lead to significant advancements.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Richardson, Timothy I — Indiana University Indianapolis
- Study coordinator: Richardson, Timothy I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.