Targeting a gene linked to drug resistance in head and neck cancer
Inhibition of lysosomal flux in carcinogen-induced head and neck cancer
This study is looking at how a specific gene called TMEM16A affects head and neck cancer, especially how it helps cancer cells survive and resist treatment, with the hope of finding better ways to help patients fight this tough disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10993897 on NIH RePORTER |
What this research studies
This research investigates the role of the TMEM16A gene in squamous cell carcinoma of the head and neck (SCCHN), a type of cancer known for its poor prognosis. The study aims to understand how TMEM16A contributes to the survival of cancer cells and their resistance to chemotherapy, particularly focusing on the process of lysosomal exocytosis, which may help cancer cells expel toxic drugs. By analyzing genetic data and cellular responses, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients with SCCHN.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with squamous cell carcinoma of the head and neck who are undergoing treatment.
Not a fit: Patients with other types of cancers or those not diagnosed with head and neck cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the effectiveness of chemotherapy for head and neck cancer patients.
How similar studies have performed: Previous research has shown that targeting similar genetic pathways can improve treatment responses in other cancer types, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Duvvuri, Umamaheswar — New York University School of Medicine
- Study coordinator: Duvvuri, Umamaheswar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.