Targeting a complex involved in RNA modification linked to cancer
Small molecules to target the RNA methyltransferase complex METTL3/METTL14
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10900785
This study is looking for new ways to help treat cancer by finding small molecules that can block a specific protein complex that affects how genes work, which could lead to better treatments for different types of cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10900785 on ClinicalTrials.gov |
What this research studies
This research investigates the METTL3/METTL14 RNA methyltransferase complex, which plays a crucial role in modifying RNA molecules that regulate gene expression. By identifying small molecules that can inhibit this complex, the research aims to understand how changes in its activity can influence cancer development. The approach includes screening a large library of chemical compounds to find effective inhibitors that could potentially be used as therapeutic agents. This work could lead to new treatments for various cancers associated with dysregulation of this complex.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers that exhibit hyperactivity of the METTL3/METTL14 complex, such as certain types of adenocarcinomas.
Not a fit: Patients with cancers not associated with METTL3/METTL14 dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with cancers linked to METTL3/METTL14 dysregulation.
How similar studies have performed: Previous research has shown promise in targeting RNA modifications for cancer treatment, indicating that this approach could be a meaningful advancement in cancer therapy.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAM, YUNSUN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: NAM, YUNSUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Induction, Cancer Patient