Targeted Treatments for Heart Artery Disease
Cell-Selective Therapies for Coronary Artery Disease
This project aims to create new, precise treatments for heart artery disease by targeting specific cells that cause plaque buildup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11004710 on NIH RePORTER |
What this research studies
Heart artery disease, also known as atherosclerotic cardiovascular disease, is a major health concern worldwide. Current treatments have limitations, especially in delivering therapies directly to the diseased areas without harming healthy cells. This project is developing a new type of "nanotherapy" that uses tiny particles to deliver genetic material, like mRNA and siRNA, to specific cells within the plaque. The goal is to stop inflammation and cell growth that contribute to the disease, while also protecting the lining of blood vessels.
Who could benefit from this research
Good fit: Patients with atherosclerotic cardiovascular disease, including those at risk for plaque buildup and restenosis, are the focus of this research.
Not a fit: Patients without atherosclerotic cardiovascular disease would not directly benefit from this specific treatment approach.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and safer treatments for heart artery disease and prevent complications like restenosis after procedures.
How similar studies have performed: This research explores a novel cell-selective nanotherapy approach, building on existing knowledge of genetic therapies and targeted drug delivery.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Totary-Jain, Hana — University of South Florida
- Study coordinator: Totary-Jain, Hana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.