Targeted treatment for blood clots to prevent tissue damage
Targeted treatment of thrombotic occlusions using a dual-delivery microgel therapeutic
This study is testing a new treatment for blood clots that aims to quickly dissolve the clots and help prevent scar tissue, making recovery easier for people who have had issues like heart attacks or deep vein thrombosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10673209 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment for blood clots that can cause serious injuries to tissues, such as heart attacks and deep vein thrombosis. The approach involves using a specialized microgel that delivers two types of therapies: one to quickly dissolve the clot and restore blood flow, and another to prevent scar tissue formation that can occur afterward. By targeting the delivery of these treatments directly to the affected area, the goal is to improve recovery and reduce long-term complications for patients. This innovative method aims to address both immediate and long-term effects of thrombotic occlusions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute thrombotic events, such as myocardial infarction or deep vein thrombosis.
Not a fit: Patients with chronic thrombotic conditions or those who have already developed significant fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery outcomes for patients suffering from thrombotic occlusions by preventing tissue damage and fibrosis.
How similar studies have performed: While targeted drug delivery systems are being explored in various contexts, this specific dual-delivery approach for thrombotic occlusions is novel and has not been extensively tested.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Brown, Ashley Carson — North Carolina State University Raleigh
- Study coordinator: Brown, Ashley Carson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.