Targeted therapy for H. pylori stomach infections
Targeting NuoD for the treatment of H. pylori
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11321639
A new oral drug aimed at killing H. pylori bacteria while protecting the rest of your gut bacteria, for people with H. pylori infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11321639 on ClinicalTrials.gov |
What this research studies
This project aims to make a new, narrow antibiotic that blocks a protein (NuoD) H. pylori needs to breathe. Scientists use computer-based virtual screening to find molecules that fit that protein, then synthesize and improve the best hits. Promising compounds are being checked in lab cultures, in samples outside the body, and in animal studies to show they clear H. pylori and can be given by mouth. The goal is an effective pill that treats H. pylori infections with less damage to the rest of the gut microbiome than current broad antibiotics.
Who could benefit from this research
Good fit: People with confirmed H. pylori infection, especially those with antibiotic-resistant infections or recurrent peptic ulcers, would be the main candidates for future trials.
Not a fit: People without H. pylori, those with stomach problems from non-bacterial causes, or anyone expecting an immediately available approved treatment would likely not benefit now.
Why it matters
Potential benefit: Could produce a more reliable, narrow-spectrum oral antibiotic that clears H. pylori with fewer side effects on gut bacteria.
How similar studies have performed: Early lab tests and animal studies with related NuoD-targeting compounds have shown antibacterial activity, but this approach remains preclinical and untested in people.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, RICHARD E. — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: LEE, RICHARD E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.