Targeted radiation treatment for advanced prostate cancer without hormone therapy
Phase II Trial of targeted Radiation with no castration for mcrpc (POTENT-C)
This study is looking at a new way to treat advanced prostate cancer by using targeted radiation therapy that allows men to keep their testosterone levels normal, with the hope of improving their quality of life while fighting the cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11046544 on NIH RePORTER |
What this research studies
This research investigates a new approach for treating metastatic castration-resistant prostate cancer (mCRPC) by using targeted radiation therapy without the need for continuous medical or surgical castration. The study aims to determine if patients can maintain a better quality of life by restoring normal testosterone levels while receiving targeted radiation that specifically attacks cancer cells. By focusing on precision delivery of radiation to metastatic lesions, the research seeks to improve treatment outcomes and overall well-being for patients. Participants will be monitored for both cancer progression and quality of life improvements throughout the trial.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with metastatic castration-resistant prostate cancer who are seeking alternative treatment options.
Not a fit: Patients who have not been diagnosed with mCRPC or those who are not suitable for radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance the quality of life for patients with mCRPC by reducing side effects associated with hormone therapy.
How similar studies have performed: Previous research has shown promising results with targeted radiation therapies in similar contexts, indicating potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Nickols, Nicholas George — VA Greater Los Angeles Healthcare System
- Study coordinator: Nickols, Nicholas George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.