Targeted MDM2 Degraders for Better Triple-Negative Breast Cancer Therapy

Who could benefit from this research

What this research studies

This grant focuses on creating a first-in-class MDM2 degrader that can more effectively fight TNBC by binding to the MDM2 RING domain. Researchers will optimize the CH175 compound to increase how well it binds MDM2 and how potent it is against TNBC in preclinical models. The work involves structure-based design, chemical optimization, and screening of new CH175 analogs to move toward a potential future clinical candidate. If successful, this approach could offer a novel therapy for TNBC patients who currently have limited targeted options.

Why it matters

Where this research is happening

• University of Tennessee Health Sci Ctr
  Memphis, United States Active

Researchers

• Principal investigator: Li, Wei — University of Tennessee Health Sci Ctr
• Study coordinator: Li, Wei

Related research

Other NIH-funded projects on the same topics.

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• Rac-enhanced CAR-Macrophages against TNBC

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• A new peptide therapy to help treat metastatic triple-negative breast cancer

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  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.