Targeted cancer-prevention medicines for people with inherited cancer risk
Cancer Prevention-Interception Targeted Agent Discovery Program at Fox Chase Cancer Center
The team is developing targeted drugs to stop early cancer changes in adults who carry inherited cancer-risk mutations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11168811 on NIH RePORTER |
What this research studies
This program brings together specialists to find medicines that could prevent cancer in people with hereditary risk. They use genetic data and samples from Fox Chase’s large high-risk family program to identify molecular targets. Promising compounds will be screened in lab assays and tested in pilot animal studies before any small human studies. If a candidate looks safe and effective, it could move toward early prevention trials in people at risk.
Who could benefit from this research
Good fit: Adults (typically age 21+) with hereditary cancer syndromes or confirmed germline mutations, especially those enrolled in or near Fox Chase’s high-risk program, are the most relevant candidates.
Not a fit: People without an inherited cancer risk or those with already advanced cancers are unlikely to benefit from prevention-focused agents developed here.
Why it matters
Potential benefit: Could lead to new medicines that prevent or block early cancer development in people with inherited high cancer risk.
How similar studies have performed: Drug-discovery and targeted therapy approaches have succeeded in treating some cancers, but using them specifically to prevent early cancer in hereditary-risk populations is relatively novel and not yet proven.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Clapper, Margie L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Clapper, Margie L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.