Targeted antibiotic treatment for diarrhea caused by Shigella in young children
Official title: Targeted antibiotic therapy for Shigella among children in low-resource settings
Funded at Emory University · NIH-10938142 · Data updated 2026-11-12
This study is looking to make it easier and faster to diagnose Shigella infections in young children with diarrhea in Tanzania, so they can get the right antibiotics to help them recover quickly and grow healthy, while also helping to prevent the overuse of antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 7, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $746,813 |
| NIH project number | 1R01AI185140-01 |
| Project ID | NIH-10938142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under five years old who are hospitalized with diarrhea in low-resource settings.
✕Less likely to help
Patients who are not experiencing diarrhea or are older than five years may not benefit from this research.
What this research studies
This research focuses on improving the treatment of Shigella infections, a major cause of diarrhea and death in children under five in low-resource countries. It aims to develop better methods for diagnosing Shigella at the point-of-care, ensuring that children receive the appropriate antibiotics while minimizing unnecessary antibiotic use. By studying children hospitalized with diarrhea in Tanzania, the research will assess the impact of targeted antibiotic therapy on health outcomes, including recovery time and growth. The goal is to enhance treatment protocols and reduce the risk of antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could significantly reduce mortality and improve recovery rates for children suffering from Shigella-related diarrhea.
How similar studies have gone: Previous research has shown that targeted antibiotic therapies can improve outcomes in similar infectious diseases, suggesting a promising approach for this study.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Rogawski Mcquade, Elizabeth Tacket — Emory University
- Study coordinator: Rogawski Mcquade, Elizabeth Tacket
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.