Targeted antibiotic therapy for Shigella in young children in low-resource settings
Official title: Targeted antibiotic therapy for Shigella among children in low-resource settings
Funded at Emory University · NIH-11543039 · Data updated 2026-11-12
A new approach aims to correctly identify Shigella infections in young children with diarrhea and treat them with targeted antibiotics to improve outcomes and reduce antibiotic resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 7, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $136,169 |
| NIH project number | 3R01AI185140-03S1 |
| Project ID | NIH-11543039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children under 5 years old hospitalized with diarrhea in low-resource settings who can be tested for Shigella and monitored for antibiotic response.
✕Less likely to help
Some children with non-Shigella diarrhea or viral infections may not benefit from antibiotic targeting in this study.
What this research studies
This research will enroll children with diarrhea in low-resource settings to understand when antibiotics are truly needed for Shigella infections. It plans to use biomarker-based strategies to quickly identify Shigella at the point of care and guide treatment. The study also aims to design population-level approaches to narrow antibiotic use to confirmed Shigella cases, helping preserve antibiotics for those who need them most. The work will be conducted through a prospective cohort of hospitalized children and will consider outcomes related to diarrhea severity and resistance patterns.
Why it matters
Potential benefit: If successful, this project could improve recovery from diarrhea in children while reducing unnecessary antibiotic use and slowing antimicrobial resistance.
How similar studies have gone: Previous work suggests that accurate, rapid identification of Shigella can improve treatment decisions, but this specific biomarker-based, population-level strategy in low-resource settings is novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Rogawski Mcquade, Elizabeth Tacket — Emory University
- Study coordinator: Rogawski Mcquade, Elizabeth Tacket
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.