Targeted anti-inflammatory approaches for Alzheimer's in adults with Down syndrome
Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11177893
This project looks at blood-based inflammatory signals in adults with Down syndrome who develop Alzheimer's to find who might respond to anti-inflammatory treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11177893 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers will analyze stored blood samples from a prior vitamin E trial of older adults with Down syndrome to look for immune and inflammatory patterns. They will use high-throughput proteomics and isolate exosome subtypes to measure many proteins and signaling molecules at once. The team will compare those inflammatory signatures across people to define subgroups that may respond differently to anti-inflammatory therapies. The goal is to build a framework that helps design better, more personalized treatment trials for Alzheimer's disease in Down syndrome.
Who could benefit from this research
Good fit: Adults with Down syndrome aged 21 and older, especially those with signs or biomarkers of Alzheimer's disease, are the population this work focuses on.
Not a fit: People without Down syndrome or those whose Alzheimer's does not involve the inflammatory pathways studied may not benefit from these specific findings.
Why it matters
Potential benefit: If successful, this work could help match people with Down syndrome and Alzheimer's to anti-inflammatory treatments that are more likely to work for them.
How similar studies have performed: Similar inflammatory biomarker approaches have shown promise in sporadic Alzheimer's, and this project adapts those validated methods to the Down syndrome population, which is a newer application.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RISSMAN, ROBERT — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: RISSMAN, ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.