Tailored treatments for children with sepsis
Official title: Personalized Therapies of Pediatric Sepsis
Funded at University of Pittsburgh at Pittsburgh · NIH-11113514 · Data updated 2026-11-12
This study is looking at how to better treat children with sepsis by figuring out different types of the condition that might need different treatments, using data from their vital signs in the ICU to find more personalized and effective care for these young patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $186,221 |
| NIH project number | 1K23AI190128-01 |
| Project ID | NIH-11113514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with sepsis and admitted to an intensive care unit.
✕Less likely to help
Patients who are not diagnosed with sepsis or are outside the pediatric age range may not benefit from this research.
What this research studies
This research focuses on improving treatment for pediatric sepsis by identifying specific subtypes of the condition that may respond differently to various therapies. By analyzing continuously monitored vital sign data from children in intensive care, the study aims to uncover insights into the physiological changes associated with sepsis. This approach seeks to move away from the traditional one-size-fits-all treatment model, potentially leading to more effective and personalized therapies for young patients suffering from this life-threatening condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with sepsis, improving survival rates and outcomes.
How similar studies have gone: Previous research has shown promise in using personalized approaches to treat sepsis in adults, but this specific focus on pediatric patients is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Aldewereld, Zachary — University of Pittsburgh at Pittsburgh
- Study coordinator: Aldewereld, Zachary
Related research
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Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.