Tailored light therapy for treating inoperable lung cancer with airway obstruction

Patient tailored near real-time image-based treatment for interstitial PDT of Inoperable Cancer with Airway Obstruction - Phase IIa

['FUNDING_SBIR_2'] · SIMPHOTEK, INC. · NIH-10468238

This study is testing a new light therapy for people with inoperable lung cancer that blocks airways, making it more effective by customizing the treatment to fit each patient's unique needs during the procedure.

Quick facts

Phase['FUNDING_SBIR_2']
Study typeNih_funding
SexAll
SponsorSIMPHOTEK, INC. (nih funded)
Locations1 site (NEWARK, UNITED STATES)
Trial IDNIH-10468238 on ClinicalTrials.gov

What this research studies

This research focuses on improving treatment for patients with inoperable lung cancer that causes airway obstruction by using a specialized light therapy called interstitial photodynamic therapy (I-PDT). The approach involves real-time adjustments to the treatment based on individual patient characteristics, such as the optical properties of their tumors and the placement of treatment fibers. By utilizing advanced software, the treatment can be personalized to enhance its effectiveness during the procedure. The study aims to demonstrate the benefits of this tailored approach in a clinical setting.

Who could benefit from this research

Good fit: Ideal candidates for this research are patients diagnosed with solid malignancies in the lung that are causing central airway obstruction.

Not a fit: Patients with operable lung cancer or those without airway obstruction may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatment options for patients with inoperable lung cancer, potentially improving their quality of life and survival rates.

How similar studies have performed: Previous research has shown promise in using photodynamic therapy for cancer treatment, but this specific approach utilizing real-time adjustments is relatively novel.

Where this research is happening

NEWARK, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Cancers, neoplasm/cancer

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.