Tailored HIV care models to make treatment and prevention easier

Differentiated HIV Care Models: An Implementation Science Study

NIH-funded research Duke University · NIH-11387481

This project compares more flexible, less stigmatizing clinic approaches to usual care to help adults on HIV treatment or taking PrEP stay engaged and healthy in South Africa.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-11387481 on NIH RePORTER

What this research studies

You would be followed at several clinics in South Africa where teams are trying different ways of delivering HIV services that are more convenient and less stigmatizing. Researchers will observe clinic practices, interview staff, and do repeated in-depth interviews with clients to learn what helps or gets in the way of care. They will follow groups of adults on ART and adults taking PrEP at clinics using differentiated care and compare viral suppression and adherence to people at standard clinics. The study will also look at costs and whether adding prioritized primary care services or stigma-reduction activities improves results.

Who could benefit from this research

Good fit: Adults (about 21 years and older) living with HIV on ART or taking PrEP who receive care at participating clinics in South Africa are the ideal candidates.

Not a fit: People younger than the study age limit, those not receiving care at the participating clinics, or those outside the study regions are unlikely to directly benefit.

Why it matters

Potential benefit: If successful, this work could make HIV services easier to access, cut down stigma in clinics, and improve viral suppression and PrEP adherence.

How similar studies have performed: Other demonstration projects of differentiated service delivery in similar settings have shown promise for improving retention and viral suppression, while combining primary care integration and explicit stigma-reduction strategies is less tested.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.