Tailored exercise plus NAD+ supplement to rebuild muscle and fitness in adolescent and young adult stem-cell transplant survivors
Official title: Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
Funded at Children's Hosp of Philadelphia · NIH-11176198 · Data updated 2026-11-12
This project tests whether a personalized home exercise program combined with an NAD+ precursor supplement helps teenage and young adult stem-cell transplant survivors regain muscle mass and fitness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $692,336 |
| NIH project number | 5R01CA254955-05 |
| Project ID | NIH-11176198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Teen and young adult survivors of hematopoietic stem cell transplantation who have low muscle mass or reduced fitness and can participate in a home exercise program are the ideal candidates.
✕Less likely to help
People currently in active cancer treatment, with unstable medical conditions that make exercise unsafe, or with contraindications to nicotinamide riboside may not be able to participate or benefit.
What this research studies
If I've had a hematopoietic stem cell transplant as a teen or young adult, this program offers a personalized home-based aerobic and resistance exercise plan plus an oral NAD+ precursor called nicotinamide riboside. I would follow an intensive, tailored exercise schedule and take the supplement while the team measures my muscle mass, strength, fitness, and muscle energy function over time. The researchers will use fitness tests, body composition scans, and blood or tissue measures to track changes and safety. The aim is to find safe ways to rebuild muscle and reduce long-term health risks linked to early sarcopenia after transplant.
Why it matters
Potential benefit: If successful, this approach could rebuild muscle strength and endurance and lower long-term risks like premature cardiovascular disease in transplant survivors.
How similar studies have gone: Exercise is well known to improve muscle and mitochondrial function and short-term nicotinamide riboside has increased NAD+ in humans, but combining intensive tailored exercise with NAD+ precursors in AYA transplant survivors is a relatively new and not yet widely tested approach.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Mostoufi-Moab, Sogol — Children's Hosp of Philadelphia
- Study coordinator: Mostoufi-Moab, Sogol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.