Synapse signaling changes in autism
Investigating the synaptic pathology of Autism
The team aims to restore normal synapse signaling in brain cells with autism-linked mutations to help people with ASD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11253261 on NIH RePORTER |
What this research studies
This project looks at how proteins at nerve cell connections (synapses) talk to each other and how autism-linked genetic changes warp that network. Researchers use a lab method called quantitative multiplex co-immunoprecipitation (QMI) to measure interactions among a 20-protein network that controls synaptic signaling. They compare normal and mutation-bearing cells to see if they can shift the network back to a healthier state and whether that change fixes cellular signaling and balance. Findings could point to ways to correct synaptic dysfunction underlying some forms of autism.
Who could benefit from this research
Good fit: Most relevant are people with ASD who have known mutations in genes that affect synaptic signaling or individuals willing to donate biological samples for research.
Not a fit: People whose autism is driven by causes unrelated to synaptic signaling genes or who cannot provide samples are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to treatments that restore balanced synaptic signaling and reduce neural dysfunction linked to some forms of ASD.
How similar studies have performed: Previous lab studies by this group and others have shown network disruptions and some partial rescue in cell and animal models, but translating those findings into human treatments is still new.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Smith, Stephen Edward Paucha — Seattle Children's Hospital
- Study coordinator: Smith, Stephen Edward Paucha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.