Surgery, stenting, or medicine for people with severe carotid artery narrowing who have no symptoms
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)
This project compares adding carotid surgery or artery stents to intensive medical treatment versus intensive medical treatment alone for people with severe narrowing of the carotid artery who have not had symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11193054 on NIH RePORTER |
What this research studies
If you have severe narrowing of a carotid artery but no recent stroke or warning symptoms, this project randomly assigns people to get intensive medical care alone or to get intensive medical care plus either carotid surgery or carotid stenting. Participants are followed over time for stroke, complications, and overall health. The work runs in parallel: one arm compares surgery plus medicine to medicine alone and the other compares stenting plus medicine to medicine alone. The trial has enrolled thousands of patients at many U.S. and international sites and used a mix of on-site and remote monitoring, especially during the COVID-19 period.
Who could benefit from this research
Good fit: Adults with high-grade (severe) asymptomatic carotid artery narrowing who meet surgical and medical eligibility criteria are the ideal candidates.
Not a fit: People with symptomatic carotid disease, low-grade narrowing, or who are not candidates for surgery or stenting would not be expected to benefit directly from this project.
Why it matters
Potential benefit: If successful, the results could clarify which approach best prevents stroke and help people avoid unnecessary procedures.
How similar studies have performed: Earlier trials, including the original CREST trial, compared stenting and surgery and informed safety and outcomes, but CREST-2 is testing whether adding revascularization to modern intensive medical care provides extra stroke prevention.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Brott, Thomas G — Mayo Clinic Jacksonville
- Study coordinator: Brott, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.