Supporting HIV prevention methods for young women in South Africa and Zimbabwe

CARES: An adherence support intervention for multiple PREP methods among adolescent girls and young women in South Africa and Zimbabwe

NIH-funded research Research Triangle Institute · NIH-10990700

This study is all about helping young women in South Africa and Zimbabwe stick to their HIV prevention methods, like daily pills and injections, by providing them with support and guidance through counseling and reminders, making it easier for them to stay healthy and protected.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionResearch Triangle Institute NIH-funded
Lab location1 site (Research Triangle Park, United States)
Project IDNIH-10990700 on NIH RePORTER

What this research studies

This research focuses on improving adherence to HIV prevention methods among adolescent girls and young women in South Africa and Zimbabwe. It utilizes the Comprehensive Adherence Resource and Empowerment Support (CARES) intervention, which includes counseling, biomarker feedback, and various support strategies like phone calls and SMS. The goal is to adapt and evaluate the CARES intervention to ensure it can be effectively implemented in real-world settings, thereby enhancing the use of daily oral PrEP, injectable PrEP, and the monthly PrEP ring.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescent girls and young women in South Africa and Zimbabwe who are at risk of HIV and are considering or currently using PrEP methods.

Not a fit: Patients who are not at risk of HIV or who are not eligible for PrEP methods may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly increase adherence to HIV prevention methods, reducing the incidence of HIV among young women in these regions.

How similar studies have performed: Previous studies have shown promising results with similar adherence support interventions, indicating potential for success in this adapted approach.

Where this research is happening

Research Triangle Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.