Support to speed discoveries about resilience to Alzheimer’s
Administrative Supplement: Research Continuity Following Caregiving Responsibilities (R21AG087299)
['FUNDING_R21'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11412931
This project uses advanced computer analysis of genetic and single-cell data to find biological pathways that help some people resist Alzheimer’s disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11412931 on ClinicalTrials.gov |
What this research studies
This work applies interpretable deep learning to genetic and single-cell transcriptome data from people with and without Alzheimer’s to find biological programs that promote resilience. The supplement pays for a short-term data scientist to speed analytic pipelines, harmonize multi-omics datasets, and help prepare manuscripts. Researchers focus on making results understandable so they can point to possible therapeutic targets. The extra support helps the team recover lost time and finish planned aims so findings can move toward prevention or delay strategies.
Who could benefit from this research
Good fit: People with or at risk for Alzheimer’s who contribute genetic data, brain tissue, or join related observational cohorts would be most relevant to this work.
Not a fit: Patients seeking immediate changes in their clinical care or an available treatment are unlikely to benefit directly from this analysis-focused supplement.
Why it matters
Potential benefit: If successful, the project could reveal new targets for treatments or prevention strategies that help delay or prevent Alzheimer’s disease.
How similar studies have performed: Related genomics and single-cell studies have identified promising pathways, but using interpretable deep learning specifically to find resilience mechanisms is relatively new and still exploratory.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAI, YULIN — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: DAI, YULIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease