Support program to improve mental health of orphaned and vulnerable children in South Africa

MISC-CBO: A cluster randomized control trial to improve the mental health of OVC in South Africa

NIH-funded research University of Houston · NIH-11393517

This project trains community careworkers to use a year-long video-feedback caregiving program to help 7–11-year-old orphaned and vulnerable children in South Africa feel more emotionally secure and resilient.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Houston NIH-funded
Lab location1 site (Houston, United States)
Project IDNIH-11393517 on NIH RePORTER

What this research studies

If your child is 7–11 and in an orphan or vulnerable-care program, community-based careworkers will get special training and video-feedback tools to strengthen how they connect with children. The program, called MISC-CBO, is delivered over a year using a manual and structured sessions focused on building attachment and social connection. The research randomly assigns community organizations to deliver MISC-CBO or usual services and follows children's mental health over time. Researchers also work with a local advisory board to track implementation costs and readiness so the program could be scaled up if it works.

Who could benefit from this research

Good fit: Ideal candidates are 7–11-year-old orphaned and vulnerable children served by community-based organizations in South Africa.

Not a fit: Children outside the 7–11 age range, those not served by participating community organizations, or those needing intensive clinical psychiatric care may not benefit directly from this program.

Why it matters

Potential benefit: If successful, the program could reduce emotional and behavioral problems and strengthen resilience in children who experienced orphanhood or other vulnerabilities.

How similar studies have performed: A prior quasi-experimental feasibility trial of MISC-CBO in Sesotho-speaking children showed reductions in mental health problems, supporting this larger randomized test.

Where this research is happening

Houston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.