Support for CAR T Cell Therapy Trials in Blood Cancers
Core A: Administrative and Clinical Translational Core
This program develops gene-edited CAR T cell treatments meant to be off-the-shelf options for people with blood cancers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11192832 on NIH RePORTER |
What this research studies
If I were a patient, this program would bring together experts at the University of Pennsylvania to create gene-edited CAR T cells that could be given to many patients without custom manufacturing. The administrative core manages the regulatory, clinical operations, biostatistics, and budget support so the linked clinical trials run safely and smoothly. Several clinical trials within the program will test new CAR T designs and gene-editing methods in people with hematologic malignancies. The aim is to overcome obstacles seen in earlier CAR T trials so more patients can access effective, ready-made cell therapy.
Who could benefit from this research
Good fit: Ideal candidates are people with hematologic malignancies who meet the specific clinical trial eligibility criteria, often including those who have limited options with standard therapies.
Not a fit: People without blood cancers or those who do not meet trial health and safety criteria are unlikely to benefit from these trials.
Why it matters
Potential benefit: If successful, this work could make CAR T therapy more widely available as safer, off-the-shelf treatments for people with blood cancers.
How similar studies have performed: Patient-specific CAR T therapies have produced strong results in some blood cancers, but universal gene-edited off-the-shelf CAR T approaches are newer and remain experimental.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: June, Carl H. — University of Pennsylvania
- Study coordinator: June, Carl H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.