Supplemental idea to study how motors, the cytoskeleton, and ribosomes move and work together
Official title: Supplemental Application linked to parent grant Structural Dynamics of Molecular Motors, the Cytoskeleton, and the Ribosome
Funded at University of California at Davis · NIH-11598517 · Data updated 2026-11-12
This grant explores how cells build proteins and move cargo along the skeleton inside muscle and other tissues, which could shed light on heart, aging, and neurodegenerative diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 15, 2016 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $118,943 |
| NIH project number | 3R35GM118139-12S1 |
| Project ID | NIH-11598517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions involving muscle or heart function, aging-related cellular changes, or neurodegenerative diseases could potentially benefit from future applications of this work.
✕Less likely to help
As a basic science project, it may not yield direct treatments for individuals in the near term.
What this research studies
Researchers will use advanced, highly sensitive tools to study the steps by which ribosomes make proteins and how motor proteins and cytoskeletal filaments coordinate cargo transport under mechanical force. The work will focus on initiation of protein synthesis, RNA helicases, formation of RNA–protein clusters, and the role of AAA+ proteins in shaping microtubule orientation and length, with attention to how these processes may relate to disease. The project builds on the parent grant and aims to reveal mechanochemical details that help interpret cellular roles in development and disease. Findings could improve our understanding of how muscle and heart function are regulated at the molecular level and inform future therapies.
Why it matters
Potential benefit: A deeper molecular understanding could pave the way for new approaches to treat developmental, neurodegenerative, and muscle-related diseases by targeting protein synthesis and transport pathways.
How similar studies have gone: Prior work using similar biophysical tools has illuminated how motor proteins and ribosomes behave, supporting potential translational outcomes.
Where this research is happening
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University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Goldman, Yale E — University of California at Davis
- Study coordinator: Goldman, Yale E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.