Sugar-based multicomponent whooping cough vaccine
Carbohydrate based multi-component vaccine against Bordetella pertussis
Developing a new sugar-based vaccine to better protect babies and young children from whooping cough.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11330442 on NIH RePORTER |
What this research studies
Researchers will make lab-built sugar pieces from the whooping cough bacterium and attach them to a harmless virus shell (Qβ) to create vaccine candidates. The team will develop chemical methods to assemble these sugars, link them to the carrier, and identify which combinations trigger strong, bacteria-killing antibodies. Experiments will use laboratory and animal models to study immune responses and pick lead vaccine candidates. Promising candidates would be advanced toward future safety and effectiveness testing in people.
Who could benefit from this research
Good fit: Infants and young children who need improved protection from pertussis would be the likely candidates for future vaccine trials.
Not a fit: People not at risk for pertussis or those who cannot receive vaccines because of serious allergies may not benefit from this work.
Why it matters
Potential benefit: Could produce a more effective and longer-lasting whooping cough vaccine for infants and children.
How similar studies have performed: Conjugate vaccines and bacteriophage carriers have worked for other infections, but using synthetic pertussis sugars on a Qβ carrier is a novel approach for whooping cough.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Huang, Xuefei — Michigan State University
- Study coordinator: Huang, Xuefei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.