NIH-funded research R01 grant

Stronger, longer-lasting dental fillings

Official title: Hydrolysis-resistant resin networks for durable and multifunctional dental restorations

Funded at Ada Forsyth Institute, INC. · NIH-11195621 · Data updated 2026-11-12

This research is creating new materials for dental fillings and adhesives that will last longer and fight decay better for people needing dental restorations.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionAda Forsyth Institute, INC.
NIH-funded
Lab location1 site (Somerville, UNITED STATES)
Project startSeptember 19, 2024
Project endJune 30, 2029
Funding year2025
Award (this year)$459,595
NIH project number5R01DE033442-02
Project IDNIH-11195621 on NIH RePORTER

Who could benefit from this research

Could help

This research is foundational for anyone who currently has or will need dental fillings or restorations in the future.

Less likely to help

Patients who do not require dental fillings or restorations would not directly benefit from this specific material development.

What this research studies

Many dental fillings don't last as long as we'd like, often leading to new cavities around them. This project aims to develop advanced resins and composite materials that are much more durable than current options. We are working to make these new materials resistant to breakdown from saliva and bacteria, and also give them properties that fight germs and repel proteins. The goal is to create dental adhesives and fillings that perform better and stay strong for a longer time in your mouth.

Why it matters

Potential benefit: If successful, this work could lead to dental fillings and adhesives that last significantly longer, reducing the need for frequent replacements and preventing new cavities.

How similar studies have gone: While current dental materials have limitations, ongoing research in material science supports the potential for developing more durable and functional alternatives.

Where this research is happening

  • Ada Forsyth Institute, INC.
    Somerville, United States
    Active

Researchers

  • Principal investigator: Sun, Jirun — Ada Forsyth Institute, INC.
  • Study coordinator: Sun, Jirun

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.