Stronger, longer-lasting dental fillings

Hydrolysis-resistant resin networks for durable and multifunctional dental restorations

['FUNDING_R01'] · ADA FORSYTH INSTITUTE, INC. · NIH-11195621

This research is creating new materials for dental fillings and adhesives that will last longer and fight decay better for people needing dental restorations.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorADA FORSYTH INSTITUTE, INC. (nih funded)
Locations1 site (Somerville, UNITED STATES)
Trial IDNIH-11195621 on ClinicalTrials.gov

What this research studies

Many dental fillings don't last as long as we'd like, often leading to new cavities around them. This project aims to develop advanced resins and composite materials that are much more durable than current options. We are working to make these new materials resistant to breakdown from saliva and bacteria, and also give them properties that fight germs and repel proteins. The goal is to create dental adhesives and fillings that perform better and stay strong for a longer time in your mouth.

Who could benefit from this research

Good fit: This research is foundational for anyone who currently has or will need dental fillings or restorations in the future.

Not a fit: Patients who do not require dental fillings or restorations would not directly benefit from this specific material development.

Why it matters

Potential benefit: If successful, this work could lead to dental fillings and adhesives that last significantly longer, reducing the need for frequent replacements and preventing new cavities.

How similar studies have performed: While current dental materials have limitations, ongoing research in material science supports the potential for developing more durable and functional alternatives.

Where this research is happening

Somerville, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.