Strategies to protect mucus and reduce complications after blood cell transplants
Official title: Mucin preserving strategies to reduce allo HCT toxicities
Funded at Beckman Research Institute/city of Hope · NIH-10935664 · Data updated 2026-11-12
This study is looking at how to help patients who are getting a special type of stem cell transplant by finding ways to protect their gut health, especially from the effects of antibiotics, so they can recover better and avoid serious complications.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $775,660 |
| NIH project number | 1P01HL170046-01A1 |
| Project ID | NIH-10935664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled to undergo allogeneic hematopoietic cell transplantation who are at risk for infections and related complications.
✕Less likely to help
Patients who are not undergoing allo HCT or those with conditions unrelated to blood diseases may not benefit from this research.
What this research studies
This research focuses on improving outcomes for patients undergoing allogeneic hematopoietic cell transplantation (allo HCT) by developing strategies that preserve mucin, a protective substance in the gut. The study investigates how antibiotics, commonly used to treat infections in these patients, can harm gut microbiota and lead to severe complications like graft-versus-host disease (GVHD). By understanding the relationship between antibiotic use and gut health, the research aims to identify ways to minimize intestinal damage and improve patient recovery. Patients may be monitored for changes in gut bacteria and mucin levels during their treatment.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of severe complications and improve recovery for patients undergoing blood cell transplants.
How similar studies have gone: Previous studies have shown that managing gut microbiota can positively impact outcomes in transplant patients, suggesting that this approach may be promising.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Jenq, Robert — Beckman Research Institute/city of Hope
- Study coordinator: Jenq, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.