Stopping seizures and slowing brain tumor growth
Hong Proj-4
This project looks at how changes around brain tumors cause seizures and explores ways to stop seizures for people with brain tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11109571 on NIH RePORTER |
What this research studies
I am a person with a brain tumor and this team is studying how tumor cells and nearby neurons interact to create a cycle of seizures and tumor growth. They are focusing on components of the tumor microenvironment, such as the perineuronal net, that may drive repeated seizures. The researchers combine lab models, analysis of human tumor tissue, and clinical collaboration to link biological findings to patient problems. The aim is to identify biological targets that could be used to reduce seizures and potentially slow tumor progression.
Who could benefit from this research
Good fit: Ideal candidates would be people with primary brain tumors who experience seizures or brain-tumor-related epilepsy.
Not a fit: People without brain tumors or whose seizures come from other causes would likely not see direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could cut seizures, improve quality of life, and might also slow tumor progression for people with brain tumors.
How similar studies have performed: Preclinical studies have linked neuronal activity to glioma growth and shown seizure-related targets in models, but clinical success treating brain-tumor-related epilepsy has been limited.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Hong, Jennifer — Dartmouth College
- Study coordinator: Hong, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.