Stopping immune escape in advanced CML and MPN
Targeting Immune Escape in CML/MPN Transformation
This project develops treatments to revive T cells so people with chronic myeloid leukemia (CML) or related myeloproliferative neoplasms (MPN) are less likely to progress to aggressive blast-phase disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11235190 on NIH RePORTER |
What this research studies
If you have CML or an MPN, this work aims to prevent the disease from turning into a hard-to-treat blast crisis by tackling immune problems in the bone marrow. The team studies how leukemia stem cells evade T cells and how the bone marrow niche becomes 'leukemic,' using laboratory models and patient-derived samples to analyze molecules such as miR-142. They will look for targets and therapeutic strategies that restore T-cell activity and eliminate the stem cells that drive progression. The overall aim is to develop approaches that could stop or reverse transformation to blast-phase leukemia.
Who could benefit from this research
Good fit: People with chronic-phase CML or MPN who are at risk of progression or showing early signs of transformation would be the most relevant candidates.
Not a fit: Patients with unrelated diseases or those already in advanced, refractory blast-phase disease may not receive direct benefit from this research during the funding period.
Why it matters
Potential benefit: If successful, the project could lead to therapies that restore immune control and prevent or treat blast-phase transformation in CML/MPN patients.
How similar studies have performed: Related approaches targeting leukemia stem cells and boosting anti-leukemia immunity have shown promise in lab models, but applying immune reactivation specifically to prevent CML/MPN transformation remains largely experimental.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Zhang, Bin — Beckman Research Institute/city of Hope
- Study coordinator: Zhang, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.