Stopping early stomach cancer changes by looking at cells and genes
Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification
This project will use cell- and gene-level testing to find which people with stomach lining changes are most likely to get stomach cancer so doctors can target prevention.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11179407 on NIH RePORTER |
What this research studies
If you have a precancerous stomach condition like intestinal metaplasia or a history of Helicobacter pylori infection, this program looks at cells and genes in your stomach tissue to better predict risk. Researchers will compare molecular and genomic features between high-risk and low-risk lesions and grow tissue models outside the body to study how changes progress. The work combines single-cell sequencing, microbiology of H. pylori, and clinical information from patients to build a risk profile. The goal is to create clearer tests that could guide who needs closer watchful waiting or stronger prevention steps.
Who could benefit from this research
Good fit: Ideal candidates are people with gastric intestinal metaplasia or other precancerous stomach lesions, especially those with current or past H. pylori infection and who can provide biopsy samples and clinical information.
Not a fit: People without precancerous stomach changes or those unwilling to undergo endoscopy/biopsy are unlikely to benefit directly from this program.
Why it matters
Potential benefit: If successful, this work could help identify people at highest risk for stomach cancer earlier so they can get targeted surveillance or preventive treatment.
How similar studies have performed: Previous work shows treating H. pylori can lower stomach cancer risk and molecular markers can give clues, but comprehensive single-cell and molecular risk stratification of precancerous lesions is a newer and still-developing approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Ji, Hanlee P — Stanford University
- Study coordinator: Ji, Hanlee P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.