Stopping collagen from protecting harmful amyloid deposits in the body
Addressing Collagen Mediated Protection of Systemic Amyloid Fibrils
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-11189760
This project looks at ways to strip away the collagen that shelters amyloid protein clumps so people with systemic amyloidosis might better clear damaging deposits.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11189760 on ClinicalTrials.gov |
What this research studies
If you have systemic amyloidosis, researchers are studying why the body's collagen can surround amyloid fibrils and block their removal. The team will examine how collagen-1 interacts with amyloid in tissue samples and lab models and test approaches to break that protective coating. They plan to combine collagen-targeting strategies with methods that encourage immune cells to clear the deposits. The goal is to find ways to reduce amyloid burden that could be used alongside current treatments.
Who could benefit from this research
Good fit: Ideal candidates would be people diagnosed with systemic (non-brain) amyloidosis who have measurable amyloid deposits in organs or tissues.
Not a fit: People without systemic amyloid disease, those with amyloid limited to the brain (Alzheimer's) only, or patients in irreversible end-stage organ failure may not benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could help remove existing amyloid deposits and improve organ function for people with systemic amyloidosis.
How similar studies have performed: Earlier antibody-based efforts to clear amyloid have largely not produced clear clinical benefit, so targeting collagen protection is a relatively new approach.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACKSON, JOSEPH WILSON — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: JACKSON, JOSEPH WILSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease patient