Stopping cholera spread in Africa
Epidemiology and Ecology of Cholera in Africa
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11508805
This project tracks cholera bacteria and how it moves through communities in African countries to help stop outbreaks and protect people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11508805 on ClinicalTrials.gov |
What this research studies
If you live in an area with cholera, researchers will collect samples from sick people and local water sources and run genetic tests to see which cholera strains are present and whether bacteriophages are involved. They will combine lab results with GPS-based maps to follow how specific strains move between districts in Nigeria and Uganda. The team will watch how local actions like water, sanitation and hygiene (WASH) measures and outbreak responses affect spread over time. All information will be used to create a “cholera elimination scorecard” to guide public health actions and reduce future outbreaks.
Who could benefit from this research
Good fit: People living in cholera-affected districts in Nigeria, Uganda, or other endemic African locations, especially those with recent diarrheal illness or exposure to contaminated water, would be the ideal participants.
Not a fit: People who live outside endemic areas or who do not provide samples or participate in local surveillance are unlikely to see direct benefits from this project.
Why it matters
Potential benefit: If successful, this work could help countries stop local transmission of cholera, reduce outbreaks, and save lives.
How similar studies have performed: Previous molecular tracking work, including the team's earlier R01, has shown cholera strains often spread between areas rather than arise locally, and this project applies those proven methods toward elimination goals.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SACK, DAVID A — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SACK, DAVID A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.