Stopping cancer from returning after a stem cell transplant
Preventing Relapse After Non-myeloablative Stem Cell Transplantation: The Final Challenge
This project aims to stop cancer from returning after a stem cell transplant, especially for older or sicker patients with certain blood cancers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10929369 on NIH RePORTER |
What this research studies
For patients with blood cancers like myeloid malignancies and myeloma, a stem cell transplant can be a life-saving treatment, but sometimes the cancer comes back. This project is working on two main ways to prevent that. One approach is to better understand and boost the "graft-versus-tumor" effect, where the donor cells fight off any remaining cancer cells. The other approach involves using a new type of targeted radiation treatment before the transplant to reduce the amount of cancer in the body, making the transplant more effective.
Who could benefit from this research
Good fit: Ideal candidates are older or medically infirm patients with myeloid malignancies or myeloma who are undergoing allogeneic hematopoietic cell transplant.
Not a fit: Patients without myeloid malignancies or myeloma, or those not undergoing allogeneic hematopoietic cell transplant, would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could significantly reduce the chance of cancer relapse for patients undergoing stem cell transplants, leading to better long-term outcomes.
How similar studies have performed: The radioimmunotherapy approach is novel and has been developed in the lab, now progressing into early-stage human clinical trials.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Sandmaier, Brenda Marie — Fred Hutchinson Cancer Center
- Study coordinator: Sandmaier, Brenda Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.