Stopping Bourbon virus from entering human cells
Mechanism and Inhibition of Thogotovirus Entry
Researchers are testing antibodies and other blockers to stop Bourbon virus from getting into human cells to help people exposed to tick-borne infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11258887 on NIH RePORTER |
What this research studies
This work focuses on Bourbon virus, a tick-borne germ that can cause severe illness in people. Researchers will study the virus's single envelope protein that allows it to attach to and enter human cells, using lab-grown proteins, virus-like particles, and specialized antibodies. They will map where antibodies bind and use structural and laboratory tests to see which antibodies block the virus from entering cells. The goal is to guide development of antibody-based treatments or preventives for people at risk of Bourbon virus.
Who could benefit from this research
Good fit: People living in or with recent travel to areas where Bourbon virus is found, especially those with recent tick exposure or willing to donate blood for antibody research, would be ideal candidates to engage with this work.
Not a fit: People without risk of tick exposure or whose illness is caused by unrelated pathogens are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: Could lead to antibody-based therapies or preventive measures that reduce severe disease from Bourbon virus infection.
How similar studies have performed: Antibody approaches have proven useful against other enveloped viruses, but blocking class III fusion proteins like Bourbon virus's glycoprotein is relatively new and more experimental.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Boon, Adrianus Cm — Washington University
- Study coordinator: Boon, Adrianus Cm
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.