Stomach tissue pathology services to study gastric cancer
Gastric Histopathology
This program helps researchers learn how H. pylori and other changes in stomach tissue lead to gastric inflammation and cancer by analyzing animal models and donated human samples.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11307039 on NIH RePORTER |
What this research studies
From a patient's perspective, this core provides expert examination of stomach tissues to identify inflammation, precancerous changes, and tumors. The team runs specialized lab tests like immunohistochemistry and multiplex staining, creates tissue microarrays, and digitally archives slides for detailed analysis. They compare findings from rodent models of H. pylori-induced disease with samples from people to link laboratory results to real patient outcomes. The core also partners with labs doing proteomics and metabolomics to connect tissue appearances with molecular changes.
Who could benefit from this research
Good fit: People with stomach cancer, precancerous stomach conditions, or active H. pylori infection who are undergoing biopsies or stomach surgery and can donate tissue are the most relevant candidates.
Not a fit: Healthy people not having stomach tissue removed or patients with unrelated conditions would not typically participate or directly benefit from this core's work.
Why it matters
Potential benefit: If successful, this work could improve diagnosis and understanding of stomach cancer and help guide development of better treatments and tests.
How similar studies have performed: Pathology, immunostaining, and tissue microarrays are well-established methods that have previously helped link H. pylori infection to gastric cancer and improve tissue-based diagnosis.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Piazuelo, Maria Blanca — Vanderbilt University Medical Center
- Study coordinator: Piazuelo, Maria Blanca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.