Stereospecific cross-coupling to create 3D drug-like molecules
Official title: Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification
Funded at City College of New York · NIH-11348196 · Data updated 2026-11-12
This grant explores new ways to build three-dimensional, single-enantiomer drug candidates using stereoselective chemical reactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2018 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $326,560 |
| NIH project number | 5R01GM131079-08 |
| Project ID | NIH-11348196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient recruitment; the work is at the chemistry development stage for future therapeutics.
✕Less likely to help
No immediate patient participation or direct benefit in this basic chemistry phase.
What this research studies
Researchers plan to use enantioenriched organometallic building blocks and metal-catalyzed reactions to create diverse libraries of 3D, single-enantioenplete drug-like molecules. They will study how absolute stereochemistry can be introduced and reliably transferred through stereoretentive or stereoinvertive cross-coupling, enabling rapid production of varied structures. The work focuses on palladium and copper-catalyzed cross-couplings with medicinally relevant frameworks to access previously hard-to-get chiral motifs. This approach aims to streamline the generation of biologically testable compounds for assays.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of diverse, stereochemically defined drug candidates.
How similar studies have gone: Previous cross-coupling methods have shown promise in creating chiral drug-like molecules, with this project aiming to extend and generalize those capabilities.
Where this research is happening
-
City College of New York
New York, United States Active
Researchers
- Principal investigator: Biscoe, Mark Roger — City College of New York
- Study coordinator: Biscoe, Mark Roger
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.