Stepwise school program to help teens with depression in Pakistan

School based stepped care TrEatment for adolescent depression in Pakistan- a Sequential Multiple Assignment Randomized Trial (SMART-STEP)

NIH-funded research Shifa Tameer-E-Millat University · NIH-11137660

This project offers a stepped school program combining online teacher training and a CBT-based chatbot to help Pakistani adolescents with depression and anxiety.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionShifa Tameer-E-Millat University NIH-funded
Lab location1 site (Islamabad, Pakistan)
Project IDNIH-11137660 on NIH RePORTER

What this research studies

You and other students in participating public schools would get access to school-based supports: teachers receive online training to recognize and respond to common mental health problems, and students with symptoms can use a self-help chatbot based on cognitive behavioral therapy. The program uses a SMART (adaptive) design that changes the next step of care for young people who do not improve, so treatment is personalized over time. The team built the program from earlier pilots of the teacher training (eSMHP) and the STARS chatbot and will test how to best combine and sequence these supports across schools. The work is run through the SHINE network with implementation in Pakistani public schools.

Who could benefit from this research

Good fit: Teenagers enrolled in participating low-resource public schools in Pakistan who are experiencing symptoms of depression or anxiety are the ideal candidates.

Not a fit: Students with severe mental illness needing urgent psychiatric care, those not attending school, or those without access to a smartphone/internet may not benefit from this school-based digital approach.

Why it matters

Potential benefit: If successful, this could expand accessible, school-based mental health support and reduce depression and anxiety among adolescents in Pakistan.

How similar studies have performed: Early pilot work showed the online teacher training and the CBT chatbot are feasible and promising, but using a stepped SMART design to personalize school-based care is relatively new.

Where this research is happening

Islamabad, Pakistan

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.