Statins after lobar brain hemorrhage — MRI monitoring
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11396143 · Data updated 2026-11-12
This project compares continuing versus stopping statin medicines in people who had a lobar brain bleed to see how small-bleed markers on brain MRI change over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,552 |
| NIH project number | 3U01NS120871-02S2 |
| Project ID | NIH-11396143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who recently had a lobar intracerebral hemorrhage and were taking statins at the time of the bleed, who can undergo MRI and attend follow-up visits, are the ideal candidates.
✕Less likely to help
People who did not have a lobar ICH, who were not on statins, or who cannot have an MRI (for example due to incompatible implants) are unlikely to be eligible or to benefit from this study.
What this research studies
If you join, you will be part of the SATURN trial and randomized to either keep taking your statin medicine or stop it. You will get a standardized brain MRI at the start and again at 24 months to look for new small bleeds (microbleeds) and surface blood staining (cortical superficial siderosis). Doctors will compare how these MRI markers change between the two groups and link them to heart and vascular events, and to long-term thinking and daily functioning. The goal is to learn whether continuing statins changes the risk of new bleeding-related MRI findings while also tracking cardiovascular outcomes and quality of life.
Why it matters
Potential benefit: If successful, this could help doctors know whether staying on or stopping statins after a lobar brain hemorrhage is safer for your brain and heart in the long run.
How similar studies have gone: There are currently no prospective randomized data on continuing versus stopping statins after ICH, so this MRI ancillary study is a novel addition to the ongoing SATURN trial.
Where this research is happening
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Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.