Statins after lobar brain hemorrhage — MRI monitoring
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
['FUNDING_U01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11396143
This project compares continuing versus stopping statin medicines in people who had a lobar brain bleed to see how small-bleed markers on brain MRI change over two years.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11396143 on ClinicalTrials.gov |
What this research studies
If you join, you will be part of the SATURN trial and randomized to either keep taking your statin medicine or stop it. You will get a standardized brain MRI at the start and again at 24 months to look for new small bleeds (microbleeds) and surface blood staining (cortical superficial siderosis). Doctors will compare how these MRI markers change between the two groups and link them to heart and vascular events, and to long-term thinking and daily functioning. The goal is to learn whether continuing statins changes the risk of new bleeding-related MRI findings while also tracking cardiovascular outcomes and quality of life.
Who could benefit from this research
Good fit: Adults who recently had a lobar intracerebral hemorrhage and were taking statins at the time of the bleed, who can undergo MRI and attend follow-up visits, are the ideal candidates.
Not a fit: People who did not have a lobar ICH, who were not on statins, or who cannot have an MRI (for example due to incompatible implants) are unlikely to be eligible or to benefit from this study.
Why it matters
Potential benefit: If successful, this could help doctors know whether staying on or stopping statins after a lobar brain hemorrhage is safer for your brain and heart in the long run.
How similar studies have performed: There are currently no prospective randomized data on continuing versus stopping statins after ICH, so this MRI ancillary study is a novel addition to the ongoing SATURN trial.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SELIM, MAGDY H — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: SELIM, MAGDY H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.