Statins after intracerebral hemorrhage — MRI follow-up
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
['FUNDING_U01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10795710
This project compares continuing versus stopping statin medicines in people who had a lobar intracerebral hemorrhage, using brain MRIs to look for new bleeding‑related changes.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10795710 on ClinicalTrials.gov |
What this research studies
If you join, you would be part of the SATURN trial and get a standard brain MRI soon after enrollment and again at 24 months to look for small bleeding markers called cerebral microbleeds and cortical superficial siderosis. Participants who were taking statins are randomized to either keep taking them or stop, and MRI scans will be read by experts who do not know which treatment you received. The study will also compare rates of repeat brain bleeding, heart and blood vessel events, and longer-term thinking and daily function between the groups. Researchers will test whether MRI findings at the start can help predict who benefits or is harmed by continuing statins.
Who could benefit from this research
Good fit: Adults who recently had a lobar intracerebral hemorrhage and were taking statin medication at the time of their bleed are the main candidates for this study.
Not a fit: People without lobar ICH, those not on statins, or those who cannot safely undergo MRI (for example due to certain implants) are unlikely to be eligible or benefit from this specific study.
Why it matters
Potential benefit: Results could help doctors decide whether to continue or stop statins after lobar ICH to reduce the risk of repeat brain bleeding while protecting against heart and vascular events.
How similar studies have performed: There are currently no prospective randomized studies directly answering this question, so this MRI ancillary study is relatively novel in tracking new bleeding markers after statin continuation versus discontinuation.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SELIM, MAGDY H — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: SELIM, MAGDY H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.