Statin use after lobar intracerebral hemorrhage
Official title: StATins Use in intRacerebral hemorrhage patieNts (SATURN)
Funded at Beth Israel Deaconess Medical Center · NIH-11325727 · Data updated 2026-11-12
This trial compares continuing versus stopping statin medicines for people who had a lobar brain bleed and were taking statins.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2019 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $2,376,186 |
| NIH project number | 5U01NS102289-06 |
| Project ID | NIH-11325727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who suffered a lobar intracerebral hemorrhage and were taking statin medication at the time of the bleed are the main candidates for this trial.
✕Less likely to help
People with non-lobar ICH, those who were not on statins at the time of their bleed, or those unable to change statin therapy are unlikely to benefit from participating.
What this research studies
If you join, you will be randomly assigned to either keep taking your statin or stop it and then followed for 24 months. The trial is open-label (you and your doctors will know the assignment) but outcome assessors are blinded, and it enrolls patients at multiple medical centers. Researchers will track recurrent symptomatic intracerebral hemorrhage, major vascular events (like ischemic stroke or heart attack), as well as functional, cognitive, and quality-of-life outcomes. The study will also examine genetic markers (ApoE) and MRI signs such as microbleeds to see if some people face higher risk.
Why it matters
Potential benefit: If successful, the results could clarify whether continuing or stopping statins after lobar ICH better protects patients from repeat brain bleeds while balancing prevention of heart and ischemic stroke events.
How similar studies have gone: There are no prior randomized trials on this specific question; observational data show statins reduce cardiovascular events but may modestly raise ICH risk in lobar cases, leaving the approach untested in randomized settings.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
-
Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
-
Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
-
Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
-
Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.