Statin use after intracerebral hemorrhage with MRI follow-up
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
This research compares continuing versus stopping statin medicines after lobar intracerebral hemorrhage to see how they affect MRI signs of brain bleeding and small vessel disease in people who were already taking statins.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11396134 on NIH RePORTER |
What this research studies
If you join, you'll be part of a larger trial where people who had lobar intracerebral hemorrhage and were on statins are randomized to keep taking or stop their statin medicine. You'll get a standardized brain MRI at the start and again at 24 months to look for new cerebral microbleeds or cortical superficial siderosis, which are MRI markers of small vessel disease and bleeding risk. The study compares how often new hemorrhagic MRI markers appear between the two groups and examines whether baseline MRI findings help predict who benefits or is harmed by continuing statins. Your memory, thinking, and functional outcomes may also be followed as part of the parent SATURN trial.
Who could benefit from this research
Good fit: Ideal candidates are adults with lobar intracerebral hemorrhage who were taking statins at the time of their bleed, can undergo MRI, and can join the parent SATURN trial at a participating site.
Not a fit: People who never took statins, who have non-lobar (deep) ICH, or who cannot have MRI scans are unlikely to qualify or directly benefit from this MRI-focused ancillary study.
Why it matters
Potential benefit: If successful, results could help doctors decide whether continuing or stopping statins after lobar ICH reduces the risk of future brain bleeds while protecting against heart and blood vessel events.
How similar studies have performed: There are no prior randomized MRI-based trials on this question; existing evidence is limited to observational studies with mixed findings, so this approach is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.