Statin effects on brain scans after lobar brain hemorrhage
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11396153 · Data updated 2026-11-12
This project compares keeping versus stopping statin medicines in people who had lobar intracerebral hemorrhage to see how their brain scans change over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $68,553 |
| NIH project number | 3U01NS120871-02S3 |
| Project ID | NIH-11396153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lobar intracerebral hemorrhage who were taking statins at the time of their bleed and who are enrolled at a participating SATURN site.
✕Less likely to help
People who had non-lobar ICH, were not on statins at the time of their bleed, or who cannot undergo MRI are unlikely to directly benefit from this MRI ancillary study.
What this research studies
If you join, you'll be part of the parent SATURN trial and will be randomly assigned to either continue your statin or stop it. You'll have a standardized brain MRI at the start and another at 24 months to look for small bleeding markers such as cerebral microbleeds and cortical superficial siderosis. The study will compare new or worsening MRI findings between the two groups and test whether baseline MRI markers can help guide who should stay on statins. Imaging is read centrally with blinded reviewers to ensure consistent counting and classification of MRI markers.
Why it matters
Potential benefit: If successful, this work could help doctors decide whether it is safe to continue statins after lobar ICH and personalize care based on MRI markers.
How similar studies have gone: There are no prior randomized trials of statin continuation versus stopping after ICH and observational data are mixed, so this MRI-focused ancillary is relatively novel.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.