Statin effects on brain scans after lobar brain hemorrhage
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
This project compares keeping versus stopping statin medicines in people who had lobar intracerebral hemorrhage to see how their brain scans change over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11396153 on NIH RePORTER |
What this research studies
If you join, you'll be part of the parent SATURN trial and will be randomly assigned to either continue your statin or stop it. You'll have a standardized brain MRI at the start and another at 24 months to look for small bleeding markers such as cerebral microbleeds and cortical superficial siderosis. The study will compare new or worsening MRI findings between the two groups and test whether baseline MRI markers can help guide who should stay on statins. Imaging is read centrally with blinded reviewers to ensure consistent counting and classification of MRI markers.
Who could benefit from this research
Good fit: Adults with lobar intracerebral hemorrhage who were taking statins at the time of their bleed and who are enrolled at a participating SATURN site.
Not a fit: People who had non-lobar ICH, were not on statins at the time of their bleed, or who cannot undergo MRI are unlikely to directly benefit from this MRI ancillary study.
Why it matters
Potential benefit: If successful, this work could help doctors decide whether it is safe to continue statins after lobar ICH and personalize care based on MRI markers.
How similar studies have performed: There are no prior randomized trials of statin continuation versus stopping after ICH and observational data are mixed, so this MRI-focused ancillary is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.